The Non-catalytic B Subunit of Coagulation Factor XIII Accelerates Fibrin Cross-linking
نویسندگان
چکیده
منابع مشابه
Fibrin cross-linking in congenital factor XIII deficiency.
Homozygous patients with factor XIII deficiency are devoid of immunologically identifiable A protein, the active enzymatic component. Quantitative studies of transamidase activity of the factor are available in only a few cases, and the fibrin cross-linking pattern is not well known. The present paper deals with the quantitative estimation of factor XIII transamidase activity (dansylcadaverine ...
متن کاملThe factor XIII V34L polymorphism accelerates thrombin activation of factor XIII and affects cross-linked fibrin structure.
Factor XIII on activation by thrombin cross-links fibrin. A common polymorphism Val to Leu at position 34 in the FXIII A subunit is under investigation as a risk determinant of thrombosis. Because Val34Leu is close to the thrombin cleavage site, the hypothesis that it would alter the function of FXIII was tested. Analysis of FXIII subunit proteolysis by thrombin using sodium dodecyl sulfate-pol...
متن کاملCharacterization of the Catalytic Subunit of Factor XIII
Plasma factor XIII is composed of two subunits, a and b, whereas platelet and other intracellular zymogens have only a-subunits. The catalytic subunit, a. is the same in all forms. In order to characterize the interactions of awith b-chains in the plasma zymogen and a-chains with other molecules and to correlate factor XIII activity with aprotein. a specific, sensitive radioimmunoassay was deve...
متن کاملCharacterization of the catalytic subunit of factor XIII by radioimmunoassay.
Plasma factor XIII is composed of two subunits, a and b, whereas platelet and other intracellular zymogens have only a-subunits. The catalytic subunit, a, is the same in all forms. In order to characterize the interactions of 1- with b-chains in the plasma zymogen and a-chains with other molecules and to correlate factor XIII activity with a-protein, a specific, sensitive radioimmunoassay was d...
متن کاملGenetic Factors Influencing Coagulation Factor XIII B-Subunit Contribute to Risk of Ischemic Stroke
BACKGROUND AND PURPOSE Abnormal coagulation has been implicated in the pathogenesis of ischemic stroke, but how this association is mediated and whether it differs between ischemic stroke subtypes is unknown. We determined the shared genetic risk between 14 coagulation factors and ischemic stroke and its subtypes. METHODS Using genome-wide association study results for 14 coagulation factors ...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2015
ISSN: 0021-9258
DOI: 10.1074/jbc.m114.608570